Effect of 6-mercaptopurine on antibody production.
R Schwartz, J Stack… - Proceedings of the Society …, 1958 - journals.sagepub.com
R Schwartz, J Stack, W Dameshek
Proceedings of the Society for Experimental Biology and Medicine, 1958•journals.sagepub.comThe effect of 6-MP on antibody response of hyperimmunized rabbits has been studied. 2.
When given simultaneously with the antigen, 6-MP profoundly suppresses the formation of
humoral antibody. When given prior to antigenic stimulation, the effect of 6-MP on antibody
production is slight. There is no effect on amount of antibody in the serum when 6-MP is
given during the height of antibody production. 3. It has been tentatively concluded that the
action 6-MP is on the primary antibody response, rather than on the anamnestic response.
When given simultaneously with the antigen, 6-MP profoundly suppresses the formation of
humoral antibody. When given prior to antigenic stimulation, the effect of 6-MP on antibody
production is slight. There is no effect on amount of antibody in the serum when 6-MP is
given during the height of antibody production. 3. It has been tentatively concluded that the
action 6-MP is on the primary antibody response, rather than on the anamnestic response.
Summary
1. The effect of 6-MP on antibody response of hyperimmunized rabbits has been studied. 2. When given simultaneously with the antigen, 6-MP profoundly suppresses the formation of humoral antibody. When given prior to antigenic stimulation, the effect of 6-MP on antibody production is slight. There is no effect on amount of antibody in the serum when 6-MP is given during the height of antibody production. 3. It has been tentatively concluded that the action 6-MP is on the primary antibody response, rather than on the anamnestic response.
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