Canine liver homotransplants: The effect of host and graft irradiation

TE Starzl, GW Butz, DR Brock, JT Linman… - Archives of …, 1962 - jamanetwork.com
With homografts of various tissues and organs, systemic histologic changes in the host
animal are not usually detectable. Recently, however, in studying whole-organ homografts
of the canine liver, widespread changes which were coincident with rejection were found in
host organs. 6 The changes consisted of round cell infiltration and mesenchymal tissue
proliferation. They were found in bone marrow, lung, kidney, and other tissue and organs
which are constituents of the reticuloendothelial system. From the information available, it …