Hypersecretion of gastric inhibitory polypeptide in nondiabetic children with cystic fibrosis
SA Ross, D Morrison, RC McArthur - Pediatrics, 1981 - publications.aap.org
Failure of secretion of an insulinotropic enteric hormone has been postulated as a cause for
the impaired insulin secretion observed following a glycemic stimulus in children with cystic
fibrosis (CF). Gastric inhibitory polypeptide (GIP), a hormone located primarily in the
duodenum, is the main hormonal stimulus to insulin release from the gastrointestinal tract.
To determine whether hyposecretion of GIP was present in CF subjects, GIP secretion was
measured in 15 control children and ten children with CF, following a standard oral glucose …
the impaired insulin secretion observed following a glycemic stimulus in children with cystic
fibrosis (CF). Gastric inhibitory polypeptide (GIP), a hormone located primarily in the
duodenum, is the main hormonal stimulus to insulin release from the gastrointestinal tract.
To determine whether hyposecretion of GIP was present in CF subjects, GIP secretion was
measured in 15 control children and ten children with CF, following a standard oral glucose …