The exoerythrocytic stage of Plasmodium falciparum has remained a difficult phase of the
parasite life-cycle to study. The host and tissue specificity of the parasite requires the
experimental infection of humans or non-human primates and subsequent surgical recovery
of parasite-infected liver tissue to analyze this stage of the parasites development. This type
of study is impossible in humans due to obvious ethical considerations and the cost and
complexity in working with primate models has precluded their use for extensive studies of …