[HTML][HTML] FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis
A Kode, I Mosialou, BC Silva, S Joshi, M Ferron… - Journal of Biological …, 2012 - ASBMB
The Forkhead transcription factor FoxO1 inhibits through its expression in osteoblasts β-cell
proliferation, insulin secretion, and sensitivity. At least part of the FoxO1 metabolic functions
result from its ability to suppress the activity of osteocalcin, an osteoblast-derived hormone
favoring glucose metabolism and energy expenditure. In searching for mechanisms
mediating the metabolic actions of FoxO1, we focused on ATF4, because this transcription
factor also affects glucose metabolism through its expression in osteoblasts. We show here …
proliferation, insulin secretion, and sensitivity. At least part of the FoxO1 metabolic functions
result from its ability to suppress the activity of osteocalcin, an osteoblast-derived hormone
favoring glucose metabolism and energy expenditure. In searching for mechanisms
mediating the metabolic actions of FoxO1, we focused on ATF4, because this transcription
factor also affects glucose metabolism through its expression in osteoblasts. We show here …