[HTML][HTML] Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions
HH Zhao, RE Herrera, E Coronado-Heinsohn… - Journal of Biological …, 2001 - ASBMB
In a search for novel transcriptional intermediary factors for the estrogen receptor (ER), we
used the ligand-binding domain and hinge region of ER as bait in a yeast two-hybrid screen
of a cDNA library derived from tamoxifen-resistant MCF-7 human breast tumors from an in
vivo athymic nude mouse model. Here we report the isolation and characterization of the
forkhead homologue in rhabdomyosarcoma (FKHR), a recently described member of the
hepatocyte nuclear factor 3/forkhead homeotic gene family, as a nuclear hormone receptor …
used the ligand-binding domain and hinge region of ER as bait in a yeast two-hybrid screen
of a cDNA library derived from tamoxifen-resistant MCF-7 human breast tumors from an in
vivo athymic nude mouse model. Here we report the isolation and characterization of the
forkhead homologue in rhabdomyosarcoma (FKHR), a recently described member of the
hepatocyte nuclear factor 3/forkhead homeotic gene family, as a nuclear hormone receptor …