Multistep control of pituitary organogenesis
HZ Sheng, K Moriyama, T Yamashita, H Li, SS Potter… - Science, 1997 - science.org
Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the
pituitary gland in mice. Rathke's pouch is formed in two steps—first as a rudiment and later
as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive
pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and
Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages.
Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions …
pituitary gland in mice. Rathke's pouch is formed in two steps—first as a rudiment and later
as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive
pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and
Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages.
Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions …
Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps—first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4have redundant control over formation of the definitive pouch.Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.
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