Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia
M Fabbri, A Bottoni, M Shimizu, R Spizzo, MS Nicoloso… - Jama, 2011 - jamanetwork.com
Context Chromosomal abnormalities (namely 13q, 17p, and 11q deletions) have prognostic
implications and are recurrent in chronic lymphocytic leukemia (CLL), suggesting that they
are involved in a common pathogenetic pathway; however, the molecular mechanism
through which chromosomal abnormalities affect the pathogenesis and outcome of CLL is
unknown. Objective To determine whether the microRNA miR-15a/miR-16-1 cluster (located
at 13q), tumor protein p53 (TP53, located at 17p), and miR-34b/miR-34c cluster (located at …
implications and are recurrent in chronic lymphocytic leukemia (CLL), suggesting that they
are involved in a common pathogenetic pathway; however, the molecular mechanism
through which chromosomal abnormalities affect the pathogenesis and outcome of CLL is
unknown. Objective To determine whether the microRNA miR-15a/miR-16-1 cluster (located
at 13q), tumor protein p53 (TP53, located at 17p), and miR-34b/miR-34c cluster (located at …