Intracerebroventricular naltrexone treatment attenuates acquisition of intravenous cocaine self-administration in rats
NF Ramsey, JM Van Ree - Pharmacology Biochemistry and Behavior, 1991 - Elsevier
The influence of centrally administered naltrexone, an opiate antagonist, on acquisition of
intravenous cocaine self-administration behaviour in rats was examined. On five
consecutive days, three hours per day, they could self-administer a cocaine solution (30 μg
per infusion) through an indwelling cannula. Treatment consisted of daily injections of
naltrexone (2 or 5 μg) or placebo into the lateral ventricle 30 minutes before testing.
Naltrexone treatment dose dependently attenuated the rate of cocaine self-infusion. Both …
intravenous cocaine self-administration behaviour in rats was examined. On five
consecutive days, three hours per day, they could self-administer a cocaine solution (30 μg
per infusion) through an indwelling cannula. Treatment consisted of daily injections of
naltrexone (2 or 5 μg) or placebo into the lateral ventricle 30 minutes before testing.
Naltrexone treatment dose dependently attenuated the rate of cocaine self-infusion. Both …