Repeated cocaine administration upregulates K and μ, but not δ, opioid receptors
EM Unterwald, JM Rubenfeld, MJ Kreek - Neuroreport, 1994 - journals.lww.com
THE present study investigated the regulation of opioid receptors following chronic repeated
cocaine administration. Male Fischer rats were injected with saline or cocaine, 45 mg kg-1
day-1, three times daily at 1 h intervals for 14 days. Using quantitative in vitro
autoradiography, the density of k receptors was significantly higher in the rostral cingulate
cortex, rostral caudate putamen, caudal olfactory tubercle, and ventral tegmental area
following cocaine administration. No changes in [delta] receptor number were detected in …
cocaine administration. Male Fischer rats were injected with saline or cocaine, 45 mg kg-1
day-1, three times daily at 1 h intervals for 14 days. Using quantitative in vitro
autoradiography, the density of k receptors was significantly higher in the rostral cingulate
cortex, rostral caudate putamen, caudal olfactory tubercle, and ventral tegmental area
following cocaine administration. No changes in [delta] receptor number were detected in …