Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates
A Dalrymple, EJ Wild, R Joubert… - Journal of proteome …, 2007 - ACS Publications
Journal of proteome research, 2007•ACS Publications
Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities
including endocrine and immune dysfunction. HD biomarkers are needed to power clinical
trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma
changes with HD progression. Proteins of interest were evaluated using immunoblotting and
ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins
demonstrate neuroinflammation in HD and warrant further investigation as possible …
including endocrine and immune dysfunction. HD biomarkers are needed to power clinical
trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma
changes with HD progression. Proteins of interest were evaluated using immunoblotting and
ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins
demonstrate neuroinflammation in HD and warrant further investigation as possible …
Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.
Keywords: Huntington's disease • plasma • neuroinflammation • proteomics • 2D electrophoresis • LC/MS/MS • MALDI-TOF • ELISA • biomarkers
ACS Publications