Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers
MRL Stratford, A Rojas, DW Hall, MF Dennis… - Radiotherapy and …, 1992 - Elsevier
The pharmacokinetics of nicotinamide were studied in four human volunteers after oral
doses of 1–6 g. Plasma concentrations and clearance rates of the vitamin were found to be
dose-dependent, with a half-life of∼ 7–9 h for the two highest doses administered (4 and 6
g),∼ 4 h with 2 g and∼ 1.5 h with a 1-g dose. Peak concentrations ranged from 0.7 to 1.1
μmol· ml− 1 after a 6-g dose. The time to reach peak plasma concentration was dose
independent with a broad range from 0.73 to 3 h. In this study, nicotinamide had no …
doses of 1–6 g. Plasma concentrations and clearance rates of the vitamin were found to be
dose-dependent, with a half-life of∼ 7–9 h for the two highest doses administered (4 and 6
g),∼ 4 h with 2 g and∼ 1.5 h with a 1-g dose. Peak concentrations ranged from 0.7 to 1.1
μmol· ml− 1 after a 6-g dose. The time to reach peak plasma concentration was dose
independent with a broad range from 0.73 to 3 h. In this study, nicotinamide had no …