Biochemically assisted antibiotic treatment of lethal murine Staphylococcus aureus septic shock
IM Smith, LF Burmeister - The American journal of clinical nutrition, 1977 - Elsevier
Evidence has been sought for life-prolonging effects of a variety of chemicals given
subcutaneously 1 hr after intraperitoneal challenge of mice with 10 9 Staphylococcus aureus
cells. The chemicals were chosen to replace chemicals found to be missing in the blood or
carcass at death or to treat biochemical or visible abnormalities in sick mice near death from
infection. Nafcillin given subcutaneously in adequate amounts cures S. aureus infection. In
these experiments nafcillin treatment was delayed until 40% of the time from challenge to …
subcutaneously 1 hr after intraperitoneal challenge of mice with 10 9 Staphylococcus aureus
cells. The chemicals were chosen to replace chemicals found to be missing in the blood or
carcass at death or to treat biochemical or visible abnormalities in sick mice near death from
infection. Nafcillin given subcutaneously in adequate amounts cures S. aureus infection. In
these experiments nafcillin treatment was delayed until 40% of the time from challenge to …