[HTML][HTML] Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
KJ Bitterman, RM Anderson, HY Cohen… - Journal of Biological …, 2002 - ASBMB
The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase that
plays a critical role in transcriptional silencing, genome stability, and longevity. A human
homologue of Sir2, SIRT1, regulates the activity of the p53 tumor suppressor and inhibits
apoptosis. The Sir2 deacetylation reaction generates two products: O-acetyl-ADP-ribose and
nicotinamide, a precursor of nicotinic acid and a form of niacin/vitamin B 3. We show here
that nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and …
plays a critical role in transcriptional silencing, genome stability, and longevity. A human
homologue of Sir2, SIRT1, regulates the activity of the p53 tumor suppressor and inhibits
apoptosis. The Sir2 deacetylation reaction generates two products: O-acetyl-ADP-ribose and
nicotinamide, a precursor of nicotinic acid and a form of niacin/vitamin B 3. We show here
that nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and …