Atherosclerosis is a chronic disease characterised by lipid retention and inflammation in the
arterial intima. Innate immune mechanisms are central to atherogenesis, involving activation
of pattern-recognition receptors (PRRs) and induction of inflammatory processes. In a
complex tissue, such as the atherosclerotic lesion, innate signals can originate from several
sources and promote atherogenesis through ligation of PRRs. The receptors recognise
conserved molecular patterns on pathogens and endogenous products of tissue injury and …