[HTML][HTML] Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin-and dynamin-independent mechanism
E Delva, JM Jennings, CC Calkins, MD Kottke… - Journal of Biological …, 2008 - ASBMB
Pemphigus vulgaris (PV) is a life-threatening autoimmune disease characterized by oral
mucosal erosions and epidermal blistering. The autoantibodies generated target the
desmosomal cadherin desmoglein-3 (Dsg3). Previous studies demonstrate that upon PV
IgG binding, Dsg3 is internalized and enters an endo-lysosomal pathway where it is
degraded. To define the endocytic machinery involved in PV IgG-induced Dsg3
internalization, human keratinocytes were incubated with PV IgG, and various tools were …
mucosal erosions and epidermal blistering. The autoantibodies generated target the
desmosomal cadherin desmoglein-3 (Dsg3). Previous studies demonstrate that upon PV
IgG binding, Dsg3 is internalized and enters an endo-lysosomal pathway where it is
degraded. To define the endocytic machinery involved in PV IgG-induced Dsg3
internalization, human keratinocytes were incubated with PV IgG, and various tools were …