[HTML][HTML] Amyloid precursor protein trafficking, processing, and function

G Thinakaran, EH Koo - Journal of Biological Chemistry, 2008 - ASBMB
Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have
been the focus of numerous investigations over the past two decades. APP is the precursor
to the amyloid β-protein (Aβ), the 38–43-amino acid residue peptide that is at the heart of the
amyloid cascade hypothesis of Alzheimer disease (AD). Tremendous progress has been
made since the initial identification of Aβ as the principal component of brain senile plaques
of individuals with AD. Specifically, molecular characterization of the secretases involved in …