The role of IL-21 in hematological malignancies
J Ma, D Ma, C Ji - Cytokine, 2011 - Elsevier
J Ma, D Ma, C Ji
Cytokine, 2011•ElsevierIL-21, the newest member of the common γ-chain family of cytokines, has pleiotropic
biological effects through regulating a variety of immune cells. Recently, the role of IL-21 in
the treatment of cancers has been widely investigated. Conducted phase I trials in metastatic
malignant melanoma and renal cell carcinoma have shown that rIL-21 has a favorable
antitumor activity. Expression of IL-21 and IL-21R has also been found in many types of
hematological malignancies, such as chronic lymphocytic leukemia (CLL), multiple myeloma …
biological effects through regulating a variety of immune cells. Recently, the role of IL-21 in
the treatment of cancers has been widely investigated. Conducted phase I trials in metastatic
malignant melanoma and renal cell carcinoma have shown that rIL-21 has a favorable
antitumor activity. Expression of IL-21 and IL-21R has also been found in many types of
hematological malignancies, such as chronic lymphocytic leukemia (CLL), multiple myeloma …
IL-21, the newest member of the common γ-chain family of cytokines, has pleiotropic biological effects through regulating a variety of immune cells. Recently, the role of IL-21 in the treatment of cancers has been widely investigated. Conducted phase I trials in metastatic malignant melanoma and renal cell carcinoma have shown that rIL-21 has a favorable antitumor activity. Expression of IL-21 and IL-21R has also been found in many types of hematological malignancies, such as chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and lymphoma. Through binding with IL-21R, IL-21 induces activation of different JAK/STAT signal transduction pathways and regulates proliferation or apoptosis of tumor cells. In this review, we will discuss the expression of IL-21/IL-21R and its effect in different types of hematological malignancies.
Elsevier