The major pathological change in Fukuyama-type congenital muscular dystrophy brain is
polymicrogyria. Pathological studies of Fukuyama-type congenital muscular dystrophy brain
indicated that protrusion of neurons into the subarachnoid space through breaches in the
glia limitans–basal lamina complex is a cardinal pathogenic process in this condition. It
remains undetermined, however, whether the defect causing this abnormal migration
resides in the migrating neurons or in the glia limitans–basal lamina complex. To elucidate …