[HTML][HTML] Metabolic adaptations through the PGC-1α and SIRT1 pathways

JT Rodgers, C Lerin, Z Gerhart-Hines, P Puigserver - FEBS letters, 2008 - Elsevier
FEBS letters, 2008Elsevier
Energy homeostasis in mammals is achieved through tight regulation of tissue-specific
metabolic pathways that become dysregulated in metabolic diseases including diabetes and
obesity. At the molecular level, main nutrient and hormonal signaling pathways impinge on
expression of genes encoding for metabolic enzymes. Among the major components of this
transcriptional circuitry are the PGC-1α transcriptional complexes. An important regulatory
mechanism of this complex is through acetylation and SIRT1-mediated lysine de-acetylation …
Energy homeostasis in mammals is achieved through tight regulation of tissue-specific metabolic pathways that become dysregulated in metabolic diseases including diabetes and obesity. At the molecular level, main nutrient and hormonal signaling pathways impinge on expression of genes encoding for metabolic enzymes. Among the major components of this transcriptional circuitry are the PGC-1α transcriptional complexes. An important regulatory mechanism of this complex is through acetylation and SIRT1-mediated lysine de-acetylation under low nutrient conditions. Activation of SIRT1 can mimic several metabolic aspects of calorie restriction that target selective nutrient utilization and mitochondrial oxidative function to regulate energy balance. Thus, understanding the PGC-1α and SIRT1 pathways might have important implications for comprehending metabolic and age-associated diseases.
Elsevier