[HTML][HTML] Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties
A Lochter, A Srebrow, CJ Sympson, N Terracio… - Journal of Biological …, 1997 - ASBMB
Stromelysin-1 is a member of the metalloproteinase family of extracellular matrix-degrading
enzymes that regulates tissue remodeling. We previously established a transgenic mouse
model in which rat stromelysin-1 targeted to the mammary gland augmented expression of
endogenous stromelysin-1, disrupted functional differentiation, and induced mammary
tumors. A cell line generated from an adenocarcinoma in one of these animals and a
previously described mammary tumor cell line generated in culture readily invaded both a …
enzymes that regulates tissue remodeling. We previously established a transgenic mouse
model in which rat stromelysin-1 targeted to the mammary gland augmented expression of
endogenous stromelysin-1, disrupted functional differentiation, and induced mammary
tumors. A cell line generated from an adenocarcinoma in one of these animals and a
previously described mammary tumor cell line generated in culture readily invaded both a …