EGFR antagonists in cancer treatment
F Ciardiello, G Tortora - New England Journal of Medicine, 2008 - Mass Medical Soc
New England Journal of Medicine, 2008•Mass Medical Soc
Functional activation of growth factors and receptors of the epidermal growth factor receptor
(EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer
treatment. This article discusses the mechanisms of action of EGFR inhibitors, their
anticancer activity, and clinical issues concerning their use in the treatment of patients with
cancer.
(EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer
treatment. This article discusses the mechanisms of action of EGFR inhibitors, their
anticancer activity, and clinical issues concerning their use in the treatment of patients with
cancer.
Functional activation of growth factors and receptors of the epidermal growth factor receptor (EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer treatment. This article discusses the mechanisms of action of EGFR inhibitors, their anticancer activity, and clinical issues concerning their use in the treatment of patients with cancer.
The New England Journal Of Medicine