[HTML][HTML] Bacterial artificial chromosome-emulation oligonucleotide arrays for targeted clinical array-comparative genomic hybridization analyses
Z Ou, SHL Kang, CA Shaw, CE Carmack, LD White… - Genetics in …, 2008 - Elsevier
Purpose The goal of this work was to test the ability of oligonucleotide-based arrays to
reproduce the results of focused bacterial artificial chromosome (BAC)-based arrays used
clinically in comparative genomic hybridization experiments to detect constitutional copy
number changes in genomic DNA. Methods Custom oligonucleotide (oligo) arrays were
designed using the Agilent Technologies platform to give high-resolution coverage of
regions within the genome sequence coordinates of BAC/P1 artificial chromosome (PAC) …
reproduce the results of focused bacterial artificial chromosome (BAC)-based arrays used
clinically in comparative genomic hybridization experiments to detect constitutional copy
number changes in genomic DNA. Methods Custom oligonucleotide (oligo) arrays were
designed using the Agilent Technologies platform to give high-resolution coverage of
regions within the genome sequence coordinates of BAC/P1 artificial chromosome (PAC) …