Peroxisome proliferator-activated receptor γ (PPARγ) gained considerable interest as a
therapeutic target during chronic inflammatory diseases. Remarkably, the pathogenesis of
diseases such as multiple sclerosis or Alzheimer is associated with impaired PPARγ
expression. Considering that regulation of PPARγ expression during inflammation is largely
unknown, we were interested in elucidating underlying mechanisms. To this end, we
initiated an inflammatory response by exposing primary human macrophages to …