The miR-200 family: central player for gain and loss of the epithelial phenotype
S Spaderna, T Brabletz, OG Opitz - Gastroenterology, 2009 - gastrojournal.org
The hallmarks of malignant tumor progression are invasion and metastasis. Increasing
evidence indicates that activation of the embryonic program “epithelial–mesenchymal
transition”(EMT) promotes these processes by allowing detachment of cells from each other
and increasing tumor cell mobility and dissemination (Clin Exp Metastasis 24: 587–597).
EMT is a crucial embryonic program, which is activated in many developmental steps,
whenever epithelial cells or tissues need to be “transformed” to mesenchymal cells or …
evidence indicates that activation of the embryonic program “epithelial–mesenchymal
transition”(EMT) promotes these processes by allowing detachment of cells from each other
and increasing tumor cell mobility and dissemination (Clin Exp Metastasis 24: 587–597).
EMT is a crucial embryonic program, which is activated in many developmental steps,
whenever epithelial cells or tissues need to be “transformed” to mesenchymal cells or …