Objective: To highlight the use of insulin-like growth factor-I (IGF-I) measurements in the
management of acromegaly. Methods: The physiologic and pathophysiologic regulation of
growth hormone (GH) and IGF-I secretion and the role of measurements of these two
variables for diagnosing and monitoring the acromegalic condition are discussed. Results:
Chronic GH hypersecretion by pituitary tumors leads to the clinical condition of acromegaly,
characterized by enlargement of membranous bones and soft tissue overgrowth. Because of …