The GH/IGF-1 axis in growth and development: new insights derived from animal models

D Cannata, A Vijayakumar, Y Fierz… - Advances in …, 2010 - advancesinpediatrics.com
Longitudinal growth in humans follows a unique pattern that is character-ized by rapid fetal
growth, deceleration immediately after birth, a prolonged childhood growth phase, an
additional deceleration prepubertally, and a dramatic adolescent growth spurt leading
ultimately to stagnancy in adulthood [1]. Linear bone growth, which accompanies
longitudinal body growth, occurs during development and the childhood years until
epiphyseal fusion occurs after puberty [2]. Growth is dynamic in nature and is influenced by …