Variant proteins of the Plasmodium falciparum RIFIN family show distinct subcellular localization and developmental expression patterns
In order to avoid immune recognition in favor of a chronic infection, the malaria parasite
Plasmodium falciparum has developed means to express clonally variant antigens at the
surface of the infected erythrocyte (IE). Proteins of the var and rif multicopy gene families,
encoding PfEMP1 and RIFINs, respectively, have been implicated in these processes. Here,
we studied members of the latter family and present data revealing different subcellular
localization patterns for RIFIN variants belonging to two distinct subgroups, which have been …
Plasmodium falciparum has developed means to express clonally variant antigens at the
surface of the infected erythrocyte (IE). Proteins of the var and rif multicopy gene families,
encoding PfEMP1 and RIFINs, respectively, have been implicated in these processes. Here,
we studied members of the latter family and present data revealing different subcellular
localization patterns for RIFIN variants belonging to two distinct subgroups, which have been …