[HTML][HTML] Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene
KA Woods, C Camacho-Hübner… - … England Journal of …, 1996 - Mass Medical Soc
KA Woods, C Camacho-Hübner, MO Savage, AJL Clark
New England Journal of Medicine, 1996•Mass Medical SocInsulin-like growth factor I (IGF-I) mediates the majority of the growth-promoting effects of
growth hormone (GH) after birth. 1 In the prenatal period, GH does not appear to have a
major influence on fetal growth, whereas IGF-I does. Infants with congenital GH deficiency
and defects in the GH-receptor gene have only mild retardation of growth at birth, 2–4
whereas transgenic mice with a homozygous defect of the IGF-I gene (IGF-I knockout mice)
have profound embryonic and postnatal growth retardation. 5–7 Although there is no direct …
growth hormone (GH) after birth. 1 In the prenatal period, GH does not appear to have a
major influence on fetal growth, whereas IGF-I does. Infants with congenital GH deficiency
and defects in the GH-receptor gene have only mild retardation of growth at birth, 2–4
whereas transgenic mice with a homozygous defect of the IGF-I gene (IGF-I knockout mice)
have profound embryonic and postnatal growth retardation. 5–7 Although there is no direct …
Insulin-like growth factor I (IGF-I) mediates the majority of the growth-promoting effects of growth hormone (GH) after birth.1 In the prenatal period, GH does not appear to have a major influence on fetal growth, whereas IGF-I does. Infants with congenital GH deficiency and defects in the GH-receptor gene have only mild retardation of growth at birth,2–4 whereas transgenic mice with a homozygous defect of the IGF-I gene (IGF-I knockout mice) have profound embryonic and postnatal growth retardation.5–7 Although there is no direct evidence that IGF-I has a prominent role in human fetal growth, fetal tissues express IGF-I from . . .
The New England Journal Of Medicine