Clostridial neurotoxins possess discrete structural domains with distinct pharmacological
properties. Aspects of neurotoxin function with therapeutic potential include specific
neuronal binding, intracellular (cytosolic) delivery of biologically active protein and inhibition
of SNARE-mediated secretion. Understanding the structure function relationship of the
neurotoxin protein enables the creation of recombinant proteins incorporating select
domains of the neurotoxins to produce novel proteins with therapeutic potential in a range of …