[HTML][HTML] Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration

IR Rodríguez, IM Larrayoz - Journal of lipid research, 2010 - ASBMB
This review will discuss the formation and potential implications of 7-ketocholesterol (7KCh)
in the retina. 7KCh is a proinflammatory oxysterol known to be present in high amounts in
oxidized LDL deposits associated with atheromatous plaques. 7KCh is generated in situ in
these lipoprotein deposits where it can accumulate and reach very high concentrations. In
normal primate retina, 7KCh has been found associated with lipoprotein deposits in the
choriocapillaris, Bruch's membrane, and the retinal pigment epithelium (RPE). In …