Oxidative stress, KLF6 and transforming growth factor-β up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in …
P Stärkel, C Sempoux, I Leclercq, M Herin, C Deby… - Journal of …, 2003 - Elsevier
Background/Aims: Pathogenesis of non-alcoholic steatohepatitis (NASH) remains poorly
understood. Cytochrome P450 2E1 (CYP 2E1), cytokines, oxidative stress and activation of
hepatic stellate cells seem to play a role in this process. The aim was to determine the
potential implication of these factors in the progression from uncomplicated steatosis to
steatohepatitis with progressive fibrosis. Methods: Animals were fed a standard diet, a 5%
orotic acid-diet (OA) developing hepatic steatosis, or the methionine-choline deficient (MCD) …
understood. Cytochrome P450 2E1 (CYP 2E1), cytokines, oxidative stress and activation of
hepatic stellate cells seem to play a role in this process. The aim was to determine the
potential implication of these factors in the progression from uncomplicated steatosis to
steatohepatitis with progressive fibrosis. Methods: Animals were fed a standard diet, a 5%
orotic acid-diet (OA) developing hepatic steatosis, or the methionine-choline deficient (MCD) …