[HTML][HTML] E6AP and calmodulin reciprocally regulate estrogen receptor stability
Estrogen promotes the proliferation of human breast epithelial cells by interacting with the
estrogen receptor (ER). Physiological responses of cells to estrogen are regulated in part by
degradation of the ER. Previous studies revealed that calmodulin binds directly to the ER,
thereby enhancing its stability. Consistent with these findings, cell-permeable calmodulin
antagonists dramatically reduced the number of ER in MCF-7 human breast epithelial cells.
Here we investigated the molecular mechanism by which calmodulin attenuates ER …
estrogen receptor (ER). Physiological responses of cells to estrogen are regulated in part by
degradation of the ER. Previous studies revealed that calmodulin binds directly to the ER,
thereby enhancing its stability. Consistent with these findings, cell-permeable calmodulin
antagonists dramatically reduced the number of ER in MCF-7 human breast epithelial cells.
Here we investigated the molecular mechanism by which calmodulin attenuates ER …