[HTML][HTML] Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury
JM Thurman, B Renner, K Kunchithapautham… - Journal of Biological …, 2009 - ASBMB
Uncontrolled activation of the alternative pathway of complement is thought to be associated
with age-related macular degeneration (AMD). The alternative pathway is continuously
activated in the fluid phase, and tissue surfaces require continuous complement inhibition to
prevent spontaneous autologous tissue injury. Here, we examined the effects of oxidative
stress on the ability of immortalized human retinal pigment epithelial cells (ARPE-19) to
regulate complement activation on their cell surface. Combined treatment with H 2 O 2 (to …
with age-related macular degeneration (AMD). The alternative pathway is continuously
activated in the fluid phase, and tissue surfaces require continuous complement inhibition to
prevent spontaneous autologous tissue injury. Here, we examined the effects of oxidative
stress on the ability of immortalized human retinal pigment epithelial cells (ARPE-19) to
regulate complement activation on their cell surface. Combined treatment with H 2 O 2 (to …