[HTML][HTML] Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages
A Fortier, SP Faucher, K Diallo, P Gros - Immunobiology, 2011 - Elsevier
The nucleotide-binding oligomerization domain (Nod)-like receptor (NLR) family member
Naip5 plays an essential role in restricting Legionella pneumophila growth inside primary
macrophages. Upon interaction with bacterial flagellin, the intracellular receptor Naip5 forms
a multi-protein complex, the inflammasome, which activation has a protective role against
infection. The A/J mouse strain carries a Naip5 allele (Naip5A/J), which renders its
macrophages susceptible to Legionella infection. However, Naip5A/J is still competent for …
Naip5 plays an essential role in restricting Legionella pneumophila growth inside primary
macrophages. Upon interaction with bacterial flagellin, the intracellular receptor Naip5 forms
a multi-protein complex, the inflammasome, which activation has a protective role against
infection. The A/J mouse strain carries a Naip5 allele (Naip5A/J), which renders its
macrophages susceptible to Legionella infection. However, Naip5A/J is still competent for …