[HTML][HTML] FLT3/ITD mutation signaling includes suppression of SHP-1
Mutations in the FLT3 gene are the most common genetic alteration found in AML patients.
FLT3 internal tandem duplication (ITD) mutations result in constitutive activation of FLT3
tyrosine kinase activity. The consequences of this activation are an increase in total
phosphotyrosine content, persistent downstream signaling, and ultimately transformation of
hematopoietic cells to factor-independent growth. The Src homology (SH) 2 domain-
containing protein-tyrosine phosphatase (SHP)-1 is involved in the down-regulation of a …
FLT3 internal tandem duplication (ITD) mutations result in constitutive activation of FLT3
tyrosine kinase activity. The consequences of this activation are an increase in total
phosphotyrosine content, persistent downstream signaling, and ultimately transformation of
hematopoietic cells to factor-independent growth. The Src homology (SH) 2 domain-
containing protein-tyrosine phosphatase (SHP)-1 is involved in the down-regulation of a …