Intrinsic tumour suppression

SW Lowe, E Cepero, G Evan - Nature, 2004 - nature.com
SW Lowe, E Cepero, G Evan
Nature, 2004nature.com
Mutations that drive uncontrolled cell-cycle progression are requisite events in
tumorigenesis. But evolution has installed in the proliferative programmes of mammalian
cells a variety of innate tumour-suppressive mechanisms that trigger apoptosis or
senescence, should proliferation become aberrant. These contingent processes rely on a
series of sensors and transducers that act in a coordinated network to target the machinery
responsible for apoptosis and cell-cycle arrest at different points. Although oncogenic …
Abstract
Mutations that drive uncontrolled cell-cycle progression are requisite events in tumorigenesis. But evolution has installed in the proliferative programmes of mammalian cells a variety of innate tumour-suppressive mechanisms that trigger apoptosis or senescence, should proliferation become aberrant. These contingent processes rely on a series of sensors and transducers that act in a coordinated network to target the machinery responsible for apoptosis and cell-cycle arrest at different points. Although oncogenic mutations that disable such networks can have profound and varied effects on tumour evolution, they may leave intact latent tumour-suppressive potential that can be harnessed therapeutically.
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