ADAMs: key components in EGFR signalling and development

CP Blobel - Nature reviews Molecular cell biology, 2005 - nature.com
CP Blobel
Nature reviews Molecular cell biology, 2005nature.com
ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored
metalloproteases that process and shed the ectodomains of membrane-anchored growth
factors, cytokines and receptors. ADAMs also have essential roles in fertilization,
angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their
role in protein ectodomain shedding is emerging as a fertile ground for gathering new
insights into the functional regulation of membrane proteins.
Abstract
ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins.
nature.com