In vivo functions of integrins: lessons from null mutations in mice

D Sheppard - Matrix Biology, 2000 - Elsevier
D Sheppard
Matrix Biology, 2000Elsevier
The integrin family (Hynes, RO, 1992. Integrins: versatility, modulation, and signaling in cell
adhesion. Cell 69, 11–25) is composed of at least 24 heterodimers formed from eight β
subunits and 18 α subunits. Thus far, mice expressing null mutations of seven of the eight β
subunits and 13 of the 18 known α subunits have been generated, With only a few
exceptions, the phenotypes of each of the knockout lines are quite distinct. Studies utilizing
integrin knockout mice and cells derived from these mice have provided considerable and …
The integrin family (Hynes, R.O., 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11–25) is composed of at least 24 heterodimers formed from eight β subunits and 18 α subunits. Thus far, mice expressing null mutations of seven of the eight β subunits and 13 of the 18 known α subunits have been generated, With only a few exceptions, the phenotypes of each of the knockout lines are quite distinct. Studies utilizing integrin knockout mice and cells derived from these mice have provided considerable and sometimes surprising insights into unique functions of individual members of this family.
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