[HTML][HTML] Integrin α9β1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis
NE Vlahakis, BA Young, A Atakilit… - Journal of Biological …, 2007 - ASBMB
Vascular endothelial growth factor A (VEGF-A) is a potent inducer of angiogenesis. We now
show that VEGF-A-induced adhesion and migration of human endothelial cells are
dependent on the integrin α9β1 and that VEGF-A is a direct ligand for this integrin. Adhesion
and migration of these cells on the 165 and 121 isoforms of VEGF-A depend on cooperative
input from α9β1 and the cognate receptor for VEGF-A, VEGF receptor 2 (VEGF-R2). Unlike
α3β1or αvβ3 integrins, α9β1 was also found to bind the 121 isoform of VEGF-A. This …
show that VEGF-A-induced adhesion and migration of human endothelial cells are
dependent on the integrin α9β1 and that VEGF-A is a direct ligand for this integrin. Adhesion
and migration of these cells on the 165 and 121 isoforms of VEGF-A depend on cooperative
input from α9β1 and the cognate receptor for VEGF-A, VEGF receptor 2 (VEGF-R2). Unlike
α3β1or αvβ3 integrins, α9β1 was also found to bind the 121 isoform of VEGF-A. This …