[HTML][HTML] Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin α9β1: identification of a specific …

S Oommen, SK Gupta, NE Vlahakis - Journal of Biological Chemistry, 2011 - ASBMB
Integrin α9β1 mediates accelerated cell adhesion and migration through interactions with a
number of diverse extracellular ligands. We have shown previously that it directly binds the
vascular endothelial growth factors (VEGF) A, C, and D and contributes to VEGF-induced
angiogenesis and lymphangiogenesis. Until now, the α9β1 binding site in VEGF has not
been identified. Here, we report that the three-amino acid sequence, EYP, encoded by exon
3 of VEGF-A is essential for binding of VEGF to integrin α9β1 and induces adhesion and …