[HTML][HTML] The EIIIA segment of fibronectin is a ligand for integrins α9β1 and α4β1providing a novel mechanism for regulating cell adhesion by alternative splicing
YF Liao, PJ Gotwals, VE Koteliansky… - Journal of Biological …, 2002 - ASBMB
Alternative splicing of the fibronectin gene transcript gives rise to forms that include the EIIIA
(or ED-A) segment. EIIIA-containing fibronectins are prominently expressed during
embryogenesis and wound healing and appear to mediate changes in cell adhesion and
gene expression. Nonetheless, integrins that bind the EIIIA segment have not been
identified. We previously mapped the epitope for two function-blocking monoclonal
antibodies to the CC′ loop region of the EIIIA segment (Liao, Y.-F., Wieder, KG, Classen …
(or ED-A) segment. EIIIA-containing fibronectins are prominently expressed during
embryogenesis and wound healing and appear to mediate changes in cell adhesion and
gene expression. Nonetheless, integrins that bind the EIIIA segment have not been
identified. We previously mapped the epitope for two function-blocking monoclonal
antibodies to the CC′ loop region of the EIIIA segment (Liao, Y.-F., Wieder, KG, Classen …