Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism
JR Bishop, KI Stanford, JD Esko - Current opinion in lipidology, 2008 - journals.lww.com
JR Bishop, KI Stanford, JD Esko
Current opinion in lipidology, 2008•journals.lww.comA role for hepatocyte heparan sulfate in lipoprotein metabolism has now been genetically
established in mice. Given this finding, mild, but clinically relevant, hyperlipidemias in
human patients may be a result of alterations in heparan sulfate structure or possible genetic
polymorphisms in the relevant biosynthetic genes.
established in mice. Given this finding, mild, but clinically relevant, hyperlipidemias in
human patients may be a result of alterations in heparan sulfate structure or possible genetic
polymorphisms in the relevant biosynthetic genes.
Summary
A role for hepatocyte heparan sulfate in lipoprotein metabolism has now been genetically established in mice. Given this finding, mild, but clinically relevant, hyperlipidemias in human patients may be a result of alterations in heparan sulfate structure or possible genetic polymorphisms in the relevant biosynthetic genes.
Lippincott Williams & Wilkins