[HTML][HTML] JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of type II collagen, aggrecan core, and link protein …
F Legendre, J Dudhia, JP Pujol… - Journal of Biological …, 2003 - ASBMB
Signal transducers and activators of transcription (STAT) factors are cytoplasmic proteins
that can be activated by Janus kinases (JAK) and that modulate gene expression in
response to cytokine receptor stimulation. STAT proteins dimerize, translocate into the
nucleus, and activate specific target genes. In the present study, we show for the first time
that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of
JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes. Western blotting …
that can be activated by Janus kinases (JAK) and that modulate gene expression in
response to cytokine receptor stimulation. STAT proteins dimerize, translocate into the
nucleus, and activate specific target genes. In the present study, we show for the first time
that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of
JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes. Western blotting …