The influence of donor age on the survival of solid and suspension intraparenchymal human embryonic nigral grafts
TB Freeman, PR Sanberg, GM Nauert, BD Boss… - Cell …, 1995 - Elsevier
In many species, graft survival and graft-derived behavioral recovery are affected by the
embryonic donor age. We compared the ability of solid and suspension grafts of human
embryonic mesencephalic dopaminergic (DA) neurons at different embryonic stages to
survive intraparenchymal transplantation into 6-OHDA lesioned immunosuppressed rats.
Suspension grafts survived best when donor age was between postconception (PC) days 34
and 56. Transplants displayed numerous healthy tyrosine hydroxylase immunoreactive (TH …
embryonic donor age. We compared the ability of solid and suspension grafts of human
embryonic mesencephalic dopaminergic (DA) neurons at different embryonic stages to
survive intraparenchymal transplantation into 6-OHDA lesioned immunosuppressed rats.
Suspension grafts survived best when donor age was between postconception (PC) days 34
and 56. Transplants displayed numerous healthy tyrosine hydroxylase immunoreactive (TH …