[HTML][HTML] Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cells
Impaired survival signaling may represent a central mechanism in neurodegeneration. 6-
Hydroxydopamine (6-OHDA) is an oxidative neurotoxin used to injure catecholaminergic
cells of the central and peripheral nervous systems. Although 6-OHDA elicits
phosphorylation of several kinases, downstream transcriptional effects that influence
neuronal cell death are less defined. The cAMP response element (CRE) is present in the
promoter sequences of several important neuronal survival factors. Treatment of …
Hydroxydopamine (6-OHDA) is an oxidative neurotoxin used to injure catecholaminergic
cells of the central and peripheral nervous systems. Although 6-OHDA elicits
phosphorylation of several kinases, downstream transcriptional effects that influence
neuronal cell death are less defined. The cAMP response element (CRE) is present in the
promoter sequences of several important neuronal survival factors. Treatment of …