A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized …
J Villar, RM Kacmarek, L Pérez-Méndez… - Critical care …, 2006 - journals.lww.com
Objective: It has been shown in a two-center study that high positive end-expiratory pressure
(PEEP) and low tidal volume (LTV) improved outcome in ARDS. However, that study
involved patients with underlying diseases unique to the study area, was conducted at only
two centers, and enrolled a small number of patients. We similarly hypothesized that a
ventilatory strategy based on PEEP above the lower inflection point of the pressure volume
curve of the respiratory system (P flex) set on day 1 with a low tidal volume would result in …
(PEEP) and low tidal volume (LTV) improved outcome in ARDS. However, that study
involved patients with underlying diseases unique to the study area, was conducted at only
two centers, and enrolled a small number of patients. We similarly hypothesized that a
ventilatory strategy based on PEEP above the lower inflection point of the pressure volume
curve of the respiratory system (P flex) set on day 1 with a low tidal volume would result in …