[HTML][HTML] Hypoxia and β2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells
C Planès, M Blot-Chabaud, MA Matthay… - Journal of Biological …, 2002 - ASBMB
Alveolar hypoxia may impair sodium-dependent alveolar fluid transport and induce
pulmonary edema in rat and human lung, an effect that can be prevented by the inhalation of
β 2-agonists. To investigate the mechanism of β 2-agonist-mediated stimulation of sodium
transport under conditions of moderate hypoxia, we examined the effect of terbutaline on
epithelial sodium channel (ENaC) expression and activity in cultured rat alveolar epithelial
type II cells exposed to 3% O 2 for 24 h. Hypoxia reduced transepithelial sodium current and …
pulmonary edema in rat and human lung, an effect that can be prevented by the inhalation of
β 2-agonists. To investigate the mechanism of β 2-agonist-mediated stimulation of sodium
transport under conditions of moderate hypoxia, we examined the effect of terbutaline on
epithelial sodium channel (ENaC) expression and activity in cultured rat alveolar epithelial
type II cells exposed to 3% O 2 for 24 h. Hypoxia reduced transepithelial sodium current and …