Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player
D Vestweber, M Winderlich, G Cagna… - Trends in cell …, 2009 - cell.com
D Vestweber, M Winderlich, G Cagna, AF Nottebaum
Trends in cell biology, 2009•cell.comThe regulation of endothelial cell contacts is of central importance for the barrier function of
the blood vessel wall and for the control of leukocyte extravasation. In addition, the plasticity
of endothelial cell contacts is regulated during angiogenesis by growth factors, such as
vascular endothelial growth factor and angiopoietin-1. Despite the participation of several
adhesion molecules and receptors in the control of endothelial cell contacts, most of the
currently known mechanisms involve vascular endothelial cadherin (VE-cadherin), an …
the blood vessel wall and for the control of leukocyte extravasation. In addition, the plasticity
of endothelial cell contacts is regulated during angiogenesis by growth factors, such as
vascular endothelial growth factor and angiopoietin-1. Despite the participation of several
adhesion molecules and receptors in the control of endothelial cell contacts, most of the
currently known mechanisms involve vascular endothelial cadherin (VE-cadherin), an …
The regulation of endothelial cell contacts is of central importance for the barrier function of the blood vessel wall and for the control of leukocyte extravasation. In addition, the plasticity of endothelial cell contacts is regulated during angiogenesis by growth factors, such as vascular endothelial growth factor and angiopoietin-1. Despite the participation of several adhesion molecules and receptors in the control of endothelial cell contacts, most of the currently known mechanisms involve vascular endothelial cadherin (VE-cadherin), an essential adhesion molecule for the stability of endothelial junctions. Here, we focus on recent results showing how leukocytes and angiogenic factors regulate endothelial junctions.
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