The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury
KN Kangelaris, A Sapru, CS Calfee, KD Liu… - Chest, 2012 - Elsevier
Background Acute lung injury (ALI) mortality is increased among African Americans
compared with Americans of European descent, and genetic factors may be involved. A
functional T-46C polymorphism (rs2814778) in the promoter region of Duffy antigen/receptor
for chemokines (Darc) gene, present almost exclusively in people of African descent, results
in isolated erythrocyte DARC deficiency and has been implicated in ALI pathogenesis in
preclinical and murine models, possibly because of an increase in circulating Duffy-binding …
compared with Americans of European descent, and genetic factors may be involved. A
functional T-46C polymorphism (rs2814778) in the promoter region of Duffy antigen/receptor
for chemokines (Darc) gene, present almost exclusively in people of African descent, results
in isolated erythrocyte DARC deficiency and has been implicated in ALI pathogenesis in
preclinical and murine models, possibly because of an increase in circulating Duffy-binding …